Indole diterpene synthetic studies: Development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B

Amos B. Smith, László Kürti, Akin H. Davulcu, Shin Cho Young, Kazuyuki Ohmoto

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

(Chemical Equation Presented) A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald- Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.

Original languageEnglish (US)
Pages (from-to)4611-4620
Number of pages10
JournalJournal of Organic Chemistry
Volume72
Issue number13
DOIs
StatePublished - Jun 22 2007

ASJC Scopus subject areas

  • Organic Chemistry

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