Indomethacin therapy on the first day of life in infants with very low birth weight

Lynn Mahony, Randall L. Caldwell, Donald A. Girod, Roger A. Hurwitz, Robert D. Jansen, James A. Lemons, Richard L. Schreiner

Research output: Contribution to journalArticle

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Abstract

To investigate the optimal for treatment of small premature infants, we performed a double-blind, controlled trial of indomethacin therapy on the first day of life in 104 infants weighing between 700 and 1300 gm. Infants were given indomethacin or placebo at a mean age of 15 hours. Eleven of the 56 infants given placebo developed large left-to-right shunts through a patent ductus arteriosus. In contrast, only two of the 51 infants given indomethacin developed large shunts (P<0.025). There were no significant differences in incidence of surgical ligation, duration of oxygen therapy, duration of endotracheal intubation, days required to regain birth weight, or incidence of complications. However, the power of the tests of significance was low because of the small number of patients. Thus, although the incidence of large left-to-right ductus shunts was decreased in the indomethacin group, morbidity was not otherwise altered for the entire group of patients, possibly because of the relatively low incidence (21%) of large shunts in the placebo group. We conclude that although treatment with indomethacin on the first day of life appears to be safe, there is little advantage to its use in centers where the incidence of large shunts through a patent ductus arteriosus is relatively low.

Original languageEnglish (US)
Pages (from-to)801-805
Number of pages5
JournalThe Journal of Pediatrics
Volume106
Issue number5
DOIs
StatePublished - 1985

Fingerprint

Very Low Birth Weight Infant
Indomethacin
Incidence
Patent Ductus Arteriosus
Placebos
Therapeutics
Intratracheal Intubation
Birth Weight
Premature Infants
Ligation
Oxygen
Morbidity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mahony, L., Caldwell, R. L., Girod, D. A., Hurwitz, R. A., Jansen, R. D., Lemons, J. A., & Schreiner, R. L. (1985). Indomethacin therapy on the first day of life in infants with very low birth weight. The Journal of Pediatrics, 106(5), 801-805. https://doi.org/10.1016/S0022-3476(85)80361-9

Indomethacin therapy on the first day of life in infants with very low birth weight. / Mahony, Lynn; Caldwell, Randall L.; Girod, Donald A.; Hurwitz, Roger A.; Jansen, Robert D.; Lemons, James A.; Schreiner, Richard L.

In: The Journal of Pediatrics, Vol. 106, No. 5, 1985, p. 801-805.

Research output: Contribution to journalArticle

Mahony, L, Caldwell, RL, Girod, DA, Hurwitz, RA, Jansen, RD, Lemons, JA & Schreiner, RL 1985, 'Indomethacin therapy on the first day of life in infants with very low birth weight', The Journal of Pediatrics, vol. 106, no. 5, pp. 801-805. https://doi.org/10.1016/S0022-3476(85)80361-9
Mahony, Lynn ; Caldwell, Randall L. ; Girod, Donald A. ; Hurwitz, Roger A. ; Jansen, Robert D. ; Lemons, James A. ; Schreiner, Richard L. / Indomethacin therapy on the first day of life in infants with very low birth weight. In: The Journal of Pediatrics. 1985 ; Vol. 106, No. 5. pp. 801-805.
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