Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Peng Fu, Matthew Jamison, Scott La, John B. MacMillan

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Abstract

Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

Original languageEnglish (US)
Pages (from-to)5656-5659
Number of pages4
JournalOrganic Letters
Volume16
Issue number21
DOIs
StatePublished - Nov 7 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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