Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Peng Fu, Matthew Jamison, Scott La, John B. MacMillan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

Original languageEnglish (US)
Pages (from-to)5656-5659
Number of pages4
JournalOrganic Letters
Volume16
Issue number21
DOIs
StatePublished - Nov 7 2014

Fingerprint

Stereochemistry
alkaloids
Spectroscopic analysis
tryptophan
stereochemistry
spectroscopic analysis
Streptomyces
DNA-Directed RNA Polymerases
musculoskeletal system
Alkaloids
Skeleton
Amides
Tryptophan
amides
Spectrum Analysis
fragments
Spectroscopy
acids
spectroscopy
6-methylsalicylic acid

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry
  • Medicine(all)

Cite this

Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp. / Fu, Peng; Jamison, Matthew; La, Scott; MacMillan, John B.

In: Organic Letters, Vol. 16, No. 21, 07.11.2014, p. 5656-5659.

Research output: Contribution to journalArticle

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