Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models

Jane A. Foster, Ning Quan, Edra L. Stern, Krister Kristensson, Miles Herkenham

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Studies have demonstrated neuronal expression of class I major histocompatibility complex (MHC) mRNA and protein in normal and developing brain and in response to injury or viral infection. We report neuronal expression of class I MHC mRNA in hypothalamic paraventricular nucleus (PVN) neurons in rats following systemic infection with Trypanosoma brucei brucei parasites (chronic) and in response to intravenous 1 mg/kg lipopolysaccharide administration (acute peripheral) and in striatal neurons following intrastriatal 5 μg lipopolysaccharide injection (acute central). These results demonstrate that neurons can be a source of immune signaling molecules and establish class I MHC as part of the neuronal component of immune responses.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalJournal of Neuroimmunology
Volume131
Issue number1-2
DOIs
StatePublished - Oct 2002
Externally publishedYes

Keywords

  • In vivo
  • Lipopolysaccharide
  • Neuroimmune
  • Sprague-Dawley
  • Trypanosome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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