Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

M. S. Brown, J. R. Faust, J. L. Goldstein, I. Kaneko, A. Endo

Research output: Contribution to journalArticle

395 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)1121-1128
Number of pages8
JournalJournal of Biological Chemistry
Volume253
Issue number4
StatePublished - 1978

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Naphthalenes
Hydroxymethylglutaryl CoA Reductases
Enzyme Induction
Competitive Binding
Penicillium
Human Activities
Cultured Cells
Oxidoreductases
Fibroblasts
Cholesterol
Anti-Bacterial Agents
Skin
3-hydroxy-3-methylglutaryl-coenzyme A
mevastatin

ASJC Scopus subject areas

  • Biochemistry

Cite this

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title = "Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase",
author = "Brown, {M. S.} and Faust, {J. R.} and Goldstein, {J. L.} and I. Kaneko and A. Endo",
year = "1978",
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volume = "253",
pages = "1121--1128",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "4",

}

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AU - Faust, J. R.

AU - Goldstein, J. L.

AU - Kaneko, I.

AU - Endo, A.

PY - 1978

Y1 - 1978

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M3 - Article

VL - 253

SP - 1121

EP - 1128

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

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ER -