Induction of 6-thioguanine-resistant mutations by rat-liver homogenate (S9)-activated promutagens in human embryonic skin fibroblasts

Medicine & Life Sciences

• Thioguanine 82%
• Fibroblasts 43%
• Dimethylnitrosamine 41%
• Methylcholanthrene 37%
• Benzo(a)pyrene 36%
• Mutation 33%
• Skin 32%
• Liver 30%
• Survival 24%
• Hypoxanthine Phosphoribosyltransferase 20%
• Mutagens 17%
• Radiation 11%
• Proteins 10%
• Enzymes 8%

Chemical Compounds

• Promutagen 100%
• 3-Methylcholanthrene 56%
• Mutation 49%
• Benzo[a]pyrene 44%
• Chemical Mutagen 33%
• Dose 30%
• Detoxification 21%
• Protein 16%
• Mixture 8%
• Amount 8%
• Time 7%