Induction of apoptosis by tumor cell-targeted toxins

Andrew Thorburn, J. Thorburn, A. E. Frankel

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalApoptosis
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Apoptosis
  • Cancer treatment
  • Chemotherapy
  • Diphtheria toxin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

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