Induction of apoptosis by tumor cell-targeted toxins

Andrew Thorburn; J. Thorburn; A. E. Frankel

doi:10.1023/B:APPT.0000012118.95548.88

Induction of apoptosis by tumor cell-targeted toxins

Andrew Thorburn, J. Thorburn, A. E. Frankel

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.

Original language	English (US)
Pages (from-to)	19-25
Number of pages	7
Journal	Apoptosis
Volume	9
Issue number	1
DOIs	https://doi.org/10.1023/B:APPT.0000012118.95548.88
State	Published - Jan 2004

Keywords

Apoptosis
Cancer treatment
Chemotherapy
Diphtheria toxin

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Clinical Biochemistry
Cell Biology
Biochemistry, medical
Cancer Research

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10.1023/B:APPT.0000012118.95548.88

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title = "Induction of apoptosis by tumor cell-targeted toxins",

abstract = "Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.",

keywords = "Apoptosis, Cancer treatment, Chemotherapy, Diphtheria toxin",

author = "Andrew Thorburn and J. Thorburn and Frankel, {A. E.}",

note = "Funding Information: Research in our laboratories is supported by grants from NIH and the U.S. Army Breast and Prostate Cancer Research Programs.",

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AU - Thorburn, J.

AU - Frankel, A. E.

N1 - Funding Information: Research in our laboratories is supported by grants from NIH and the U.S. Army Breast and Prostate Cancer Research Programs.

PY - 2004/1

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N2 - Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.

AB - Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.

KW - Apoptosis

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KW - Chemotherapy

KW - Diphtheria toxin

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Induction of apoptosis by tumor cell-targeted toxins

Abstract

Keywords

ASJC Scopus subject areas

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