Induction of B cell tumor dormancy by anti-idiotypic antibodies

Eitan Yefenof, Louis J. Picker, Richard H. Scheuermann, Ellen S. Vitetta, Nancy E. Street, Thomas F. Tucker, Jonathan W. Uhr

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with anti-idiotype antibodies is arrested and they undergo dramatic changes in their morphology, cell-cycle status and oncogene expression. Regrowth of a tumor after long-term dormancy results from the emergence of a tumor cell variant that no longer responds to the antibodies with growth inhibition. These data demonstrate the feasibility of reversing a malignant phenotype of cells by specific growth arrest signals and suggest new approaches for therapeutic intervention in cancer.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalCurrent Opinion in Immunology
Volume5
Issue number5
DOIs
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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