Induction of cell death by magnetic actuation of nickel nanowires internalized by fibroblasts

Andrew O. Fung, Vishal Kapadia, Erik Pierstorff, Dean Ho, Yong Chen

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Magnetic nanomaterials with multimodal functionalities have emerged as a versatile platform for biomedical applications that range from basic cellular interrogation to clinical nanomedicine. In this work, we have prepared electrodeposited ferromagnetic nickel nanowires for efficient internalization into 3T3 fibroblasts. Agitation of the nanowires by a low external field induced cell death, as assessed by MTT viability assays. The response of the interleukin-6 (IL-6) gene expression of the fibroblasts to nanowire-mediated cellular manipulation was examined by quantitative real-time polymerase chain reaction (qRT-PCR). These nanowires exhibited significant potential as therapeutic and interrogative platforms for biomedicine.

Original languageEnglish (US)
Pages (from-to)15085-15088
Number of pages4
JournalJournal of Physical Chemistry C
Volume112
Issue number39
DOIs
StatePublished - Oct 2 2008
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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