Induction of Dystrophin Expression by Exon Skipping in mdx Mice Following Intramuscular Injection of Antisense Oligonucleotides Complexed with PEG-PEI Copolymers

Medicine & Life Sciences

• Inbred mdx Mouse 99%
• Dystrophin 89%
• Antisense Oligonucleotides 83%
• Intramuscular Injections 81%
• Polyethylene Glycols 80%
• Exons 60%
• Duchenne Muscular Dystrophy 21%
• Injections 20%
• poly(ethylene imine) 17%
• Transfection 15%
• Skeletal Muscle 14%
• Muscles 10%
• Mutation 5%
• Pharmaceutical Preparations 3%
• Therapeutics 2%

Chemical Compounds

• Antisense Oligonucleotide 100%
• Copolymer 47%
• Fiber 19%
• Poly(ethylene Imine) 14%
• Mutation 8%
• Poly(ethylene Glycol) 8%
• Modification 5%
• Drug 5%