Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents

Hitoshi Yamashita, Zuocheng Wang, Youxue Wang, Masahiko Segawa, Tatsuya Kusudo, Yasuhide Kontani

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the contribution of fatty acid-binding protein 3 (FABP3) to adaptive thermogenesis in brown adipose tissue (BAT) in rodents. The expression of FABP3 mRNA in BAT was regulated discriminatively in response to alteration of the ambient temperature, which regulation was similar and reciprocal to the regulation of uncoupling protein 1 (UCP1) and leptin, respectively. FABP3 expression in the BAT was significantly higher in the UCP1-knockout (KO) mice than in the wild-type ones, and these KO mice showed a higher clearance rate of free fatty acid from the plasma. In addition, FABP3 expression in the BAT was increased greatly with the development of diet-induced obesity in mice. These results indicate that the induction of FABP3 in BAT correlates with an increased demand for adaptive thermogenesis in rodents. FABP3 appears to be essential for accelerating fatty acid flux and its oxidation through UCP1 activity for non-shivering thermogenesis in BAT.

Original languageEnglish (US)
Pages (from-to)632-635
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume377
Issue number2
DOIs
StatePublished - Dec 12 2008

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Fatty Acid-Binding Proteins
Brown Adipose Tissue
Thermogenesis
Rodentia
Tissue
Knockout Mice
Essential Fatty Acids
Proteins
Nutrition
Leptin
Nonesterified Fatty Acids
Fatty Acids
Obesity
Fluxes
Diet
Plasmas
Oxidation
Messenger RNA
Temperature
Uncoupling Protein 1

Keywords

  • Adaptive thermogenesis
  • Brown adipose tissue
  • Fatty acid-binding protein 3
  • Gene expression
  • Knockout mouse
  • Uncoupling protein 1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents. / Yamashita, Hitoshi; Wang, Zuocheng; Wang, Youxue; Segawa, Masahiko; Kusudo, Tatsuya; Kontani, Yasuhide.

In: Biochemical and Biophysical Research Communications, Vol. 377, No. 2, 12.12.2008, p. 632-635.

Research output: Contribution to journalArticle

Yamashita, Hitoshi ; Wang, Zuocheng ; Wang, Youxue ; Segawa, Masahiko ; Kusudo, Tatsuya ; Kontani, Yasuhide. / Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 377, No. 2. pp. 632-635.
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