Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration

Joel K. Elmquist, Mark R. Ackermann, Karen B. Register, Richard B. Rimler, Lynne R. Ross, Carol D. Jacobson

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The functional neuroanatomy of the immune system link to the CNS was investigated by assessing neuronal activity with Fos immunohistochemistry following systemic lipopolysaccharide (LPS) administration. Two hours after LPS robust Fos-like immunoreactivity (Fos-IR) was observed in several nuclear groups in the brain including the paraventricular and supraoptic nuclei of the hypothalamus, central nucleus of the amygdala, and nucleus of the solitary tract. A similar but diminished pattern of Fos-IR was present at 6 hours and was absent 24 hours after LPS administration. Investigation of the functional neuroanatomy of the acute phase reaction could prove to be critical in enhancing the ability of individuals to combat insults such as tissue damage and inflammation.

Original languageEnglish (US)
Pages (from-to)3054-3057
Number of pages4
JournalEndocrinology
Volume133
Issue number6
StatePublished - Dec 1993

Fingerprint

Pasteurella multocida
Endotoxins
Lipopolysaccharides
Neuroanatomy
Brain
Supraoptic Nucleus
Acute-Phase Reaction
Solitary Nucleus
Paraventricular Hypothalamic Nucleus
Immune System
Immunohistochemistry
Inflammation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Elmquist, J. K., Ackermann, M. R., Register, K. B., Rimler, R. B., Ross, L. R., & Jacobson, C. D. (1993). Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. Endocrinology, 133(6), 3054-3057.

Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. / Elmquist, Joel K.; Ackermann, Mark R.; Register, Karen B.; Rimler, Richard B.; Ross, Lynne R.; Jacobson, Carol D.

In: Endocrinology, Vol. 133, No. 6, 12.1993, p. 3054-3057.

Research output: Contribution to journalArticle

Elmquist, JK, Ackermann, MR, Register, KB, Rimler, RB, Ross, LR & Jacobson, CD 1993, 'Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration', Endocrinology, vol. 133, no. 6, pp. 3054-3057.
Elmquist JK, Ackermann MR, Register KB, Rimler RB, Ross LR, Jacobson CD. Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. Endocrinology. 1993 Dec;133(6):3054-3057.
Elmquist, Joel K. ; Ackermann, Mark R. ; Register, Karen B. ; Rimler, Richard B. ; Ross, Lynne R. ; Jacobson, Carol D. / Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. In: Endocrinology. 1993 ; Vol. 133, No. 6. pp. 3054-3057.
@article{044427a4fe2b42bc8e752c993b5acb2b,
title = "Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration",
abstract = "The functional neuroanatomy of the immune system link to the CNS was investigated by assessing neuronal activity with Fos immunohistochemistry following systemic lipopolysaccharide (LPS) administration. Two hours after LPS robust Fos-like immunoreactivity (Fos-IR) was observed in several nuclear groups in the brain including the paraventricular and supraoptic nuclei of the hypothalamus, central nucleus of the amygdala, and nucleus of the solitary tract. A similar but diminished pattern of Fos-IR was present at 6 hours and was absent 24 hours after LPS administration. Investigation of the functional neuroanatomy of the acute phase reaction could prove to be critical in enhancing the ability of individuals to combat insults such as tissue damage and inflammation.",
author = "Elmquist, {Joel K.} and Ackermann, {Mark R.} and Register, {Karen B.} and Rimler, {Richard B.} and Ross, {Lynne R.} and Jacobson, {Carol D.}",
year = "1993",
month = "12",
language = "English (US)",
volume = "133",
pages = "3054--3057",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration

AU - Elmquist, Joel K.

AU - Ackermann, Mark R.

AU - Register, Karen B.

AU - Rimler, Richard B.

AU - Ross, Lynne R.

AU - Jacobson, Carol D.

PY - 1993/12

Y1 - 1993/12

N2 - The functional neuroanatomy of the immune system link to the CNS was investigated by assessing neuronal activity with Fos immunohistochemistry following systemic lipopolysaccharide (LPS) administration. Two hours after LPS robust Fos-like immunoreactivity (Fos-IR) was observed in several nuclear groups in the brain including the paraventricular and supraoptic nuclei of the hypothalamus, central nucleus of the amygdala, and nucleus of the solitary tract. A similar but diminished pattern of Fos-IR was present at 6 hours and was absent 24 hours after LPS administration. Investigation of the functional neuroanatomy of the acute phase reaction could prove to be critical in enhancing the ability of individuals to combat insults such as tissue damage and inflammation.

AB - The functional neuroanatomy of the immune system link to the CNS was investigated by assessing neuronal activity with Fos immunohistochemistry following systemic lipopolysaccharide (LPS) administration. Two hours after LPS robust Fos-like immunoreactivity (Fos-IR) was observed in several nuclear groups in the brain including the paraventricular and supraoptic nuclei of the hypothalamus, central nucleus of the amygdala, and nucleus of the solitary tract. A similar but diminished pattern of Fos-IR was present at 6 hours and was absent 24 hours after LPS administration. Investigation of the functional neuroanatomy of the acute phase reaction could prove to be critical in enhancing the ability of individuals to combat insults such as tissue damage and inflammation.

UR - http://www.scopus.com/inward/record.url?scp=0027333502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027333502&partnerID=8YFLogxK

M3 - Article

C2 - 8243337

AN - SCOPUS:0027333502

VL - 133

SP - 3054

EP - 3057

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -