Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: Role of tyrosine phosphorylation

A. P B Dackiw, K. Zakrzewski, A. B. Nathens, P. Y C Cheung, R. Fingerote, G. A. Levy, O. D. Rotstein

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The induction of a unique macrophage procoagulant molecule by routine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus- induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

Original languageEnglish (US)
Pages (from-to)5824-5828
Number of pages5
JournalJournal of Virology
Volume69
Issue number9
StatePublished - 1995

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Murine hepatitis virus
Hepatitis Viruses
Phosphotyrosine
Protein-Tyrosine Kinases
Fibrinogen
Hepatitis
Tyrosine
tyrosine
phosphorylation
macrophages
Macrophages
Phosphorylation
viral hepatitis
Viruses
viruses
fibrinogen
hepatitis
phosphotransferases (kinases)
Proteins
mice

ASJC Scopus subject areas

  • Immunology

Cite this

Dackiw, A. P. B., Zakrzewski, K., Nathens, A. B., Cheung, P. Y. C., Fingerote, R., Levy, G. A., & Rotstein, O. D. (1995). Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: Role of tyrosine phosphorylation. Journal of Virology, 69(9), 5824-5828.

Induction of macrophage procoagulant activity by murine hepatitis virus strain 3 : Role of tyrosine phosphorylation. / Dackiw, A. P B; Zakrzewski, K.; Nathens, A. B.; Cheung, P. Y C; Fingerote, R.; Levy, G. A.; Rotstein, O. D.

In: Journal of Virology, Vol. 69, No. 9, 1995, p. 5824-5828.

Research output: Contribution to journalArticle

Dackiw, APB, Zakrzewski, K, Nathens, AB, Cheung, PYC, Fingerote, R, Levy, GA & Rotstein, OD 1995, 'Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: Role of tyrosine phosphorylation', Journal of Virology, vol. 69, no. 9, pp. 5824-5828.
Dackiw, A. P B ; Zakrzewski, K. ; Nathens, A. B. ; Cheung, P. Y C ; Fingerote, R. ; Levy, G. A. ; Rotstein, O. D. / Induction of macrophage procoagulant activity by murine hepatitis virus strain 3 : Role of tyrosine phosphorylation. In: Journal of Virology. 1995 ; Vol. 69, No. 9. pp. 5824-5828.
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