Abstract
The induction of a unique macrophage procoagulant molecule by routine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus- induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.
Original language | English (US) |
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Pages (from-to) | 5824-5828 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 69 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1995 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology