Induction of murine B cell proliferation by insolubilized anti-immunoglobulins

E. Pure, E. Vitetta

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

This study demonstrates that intact antibodies specific for μ, δ, or light chains when coupled to Sepharose are effective in delivering proliferative signals to B cells. Furthermore, using Sepharose-coupled anti-δ antibodies, we have shown that hybridoma anti-δ (that is not active as soluble protein) is as effective as rabbit anti-δ in activating murine B cells. However, antibodies directed against two other surface molecules, I-A and H-2K, were not mitogenic. Thus, sIgM and sIgD are comparable in their ability to transmit a proliferative signal to the B cell and sIg seems to play a unique role in this regard.

Original languageEnglish (US)
Pages (from-to)1240-1242
Number of pages3
JournalJournal of Immunology
Volume125
Issue number3
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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