Induction of murine B cell proliferation by insolubilized anti-immunoglobulins

E. Pure, E. Vitetta

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

This study demonstrates that intact antibodies specific for μ, δ, or light chains when coupled to Sepharose are effective in delivering proliferative signals to B cells. Furthermore, using Sepharose-coupled anti-δ antibodies, we have shown that hybridoma anti-δ (that is not active as soluble protein) is as effective as rabbit anti-δ in activating murine B cells. However, antibodies directed against two other surface molecules, I-A and H-2K, were not mitogenic. Thus, sIgM and sIgD are comparable in their ability to transmit a proliferative signal to the B cell and sIg seems to play a unique role in this regard.

Original languageEnglish (US)
Pages (from-to)1240-1242
Number of pages3
JournalJournal of Immunology
Volume125
Issue number3
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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