Induction of pancreatic differentiation by signals from blood vessels

E. Lammert, O. Cleaver, D. Melton

Research output: Contribution to journalArticle

784 Citations (Scopus)

Abstract

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.

Original languageEnglish (US)
Pages (from-to)564-567
Number of pages4
JournalScience
Volume294
Issue number5542
DOIs
StatePublished - Oct 19 2001

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Blood Vessels
Insulin
Endoderm
Organogenesis
Xenopus laevis
Transgenic Mice
Endothelium
Hyperplasia
Aorta
Embryonic Structures
In Vitro Techniques
Ectopic Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Induction of pancreatic differentiation by signals from blood vessels. / Lammert, E.; Cleaver, O.; Melton, D.

In: Science, Vol. 294, No. 5542, 19.10.2001, p. 564-567.

Research output: Contribution to journalArticle

Lammert, E. ; Cleaver, O. ; Melton, D. / Induction of pancreatic differentiation by signals from blood vessels. In: Science. 2001 ; Vol. 294, No. 5542. pp. 564-567.
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