Induction of systemic autoimmunity by a xenobiotic requires endosomal TLR trafficking and signaling from the late endosome and endolysosome but not type I IFN

K. Michael Pollard, Gabriela M. Escalante, Hua Huang, Katarina M. Haraldsson, Per Hultman, Joseph M. Christy, Rahul D. Pawar, Jessica M. Mayeux, Rosana Gonzalez-Quintial, Roberto Baccala, Bruce Beutler, Argyrios N. Theofilopoulos, Dwight H. Kono

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Medicine & Life Sciences