Induction of tumor-infiltrating lymphocytes in human malignant melanoma metastases by immunization to melanoma antigen vaccine

R. Oratz, C. Cockerell, J. L. Speyer, M. Harris, D. Roses, J. C. Bystryn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report a statistically significant increase in tumor-infiltrating lymphocytes in subcutaneous melanoma metastases removed from patients immunized with a melanoma vaccine. Dense cellular infiltrates were seen in 10 of 11 nodules from vaccine-immunized patients, compared with 9 of 22 nodules from non-immunized patients (p = 0.02). Furthermore, these dense lymphocytic collections more frequently infiltrated the body of tumor nodules from immunized patients, whereas in non-immunized patients, lymphocytes were more often present only in the dermal tissue at the periphery of the nodule. Thus, allogeneic melanoma vaccines may augment immune responses to a patient's own tumor.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalJournal of Biological Response Modifiers
Volume8
Issue number4
StatePublished - 1989

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Melanoma-Specific Antigens
Tumor-Infiltrating Lymphocytes
Melanoma
Immunization
Vaccines
Neoplasm Metastasis
Neoplasms
Lymphocytes
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • Pharmacology

Cite this

Induction of tumor-infiltrating lymphocytes in human malignant melanoma metastases by immunization to melanoma antigen vaccine. / Oratz, R.; Cockerell, C.; Speyer, J. L.; Harris, M.; Roses, D.; Bystryn, J. C.

In: Journal of Biological Response Modifiers, Vol. 8, No. 4, 1989, p. 355-358.

Research output: Contribution to journalArticle

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AU - Roses, D.

AU - Bystryn, J. C.

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