Induction of tumor-infiltrating lymphocytes in human malignant melanoma metastases by immunization to melanoma antigen vaccine

R. Oratz, C. Cockerell, J. L. Speyer, M. Harris, D. Roses, J. C. Bystryn

Research output: Contribution to journalArticle

16 Scopus citations


We report a statistically significant increase in tumor-infiltrating lymphocytes in subcutaneous melanoma metastases removed from patients immunized with a melanoma vaccine. Dense cellular infiltrates were seen in 10 of 11 nodules from vaccine-immunized patients, compared with 9 of 22 nodules from non-immunized patients (p = 0.02). Furthermore, these dense lymphocytic collections more frequently infiltrated the body of tumor nodules from immunized patients, whereas in non-immunized patients, lymphocytes were more often present only in the dermal tissue at the periphery of the nodule. Thus, allogeneic melanoma vaccines may augment immune responses to a patient's own tumor.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalJournal of Biological Response Modifiers
Issue number4
StatePublished - Jan 1 1989


ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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