Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats

Michio Shimabukuro, Yan Ting Zhou, Young H Lee, Roger H Unger

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

Original languageEnglish (US)
Pages (from-to)359-361
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume237
Issue number2
DOIs
StatePublished - Aug 18 1997

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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