Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats

Michio Shimabukuro, Yan Ting Zhou, Young H Lee, Roger H Unger

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

Original languageEnglish (US)
Pages (from-to)359-361
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume237
Issue number2
DOIs
StatePublished - Aug 18 1997

Fingerprint

troglitazone
Islets of Langerhans
Rats
Messenger RNA
Leptin
Proteins
Leptin Receptors
Actins
Triglycerides
Up-Regulation
Uncoupling Protein 2

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats. / Shimabukuro, Michio; Zhou, Yan Ting; Lee, Young H; Unger, Roger H.

In: Biochemical and Biophysical Research Communications, Vol. 237, No. 2, 18.08.1997, p. 359-361.

Research output: Contribution to journalArticle

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