Ineffectiveness of cholecystokinin in impairing runway performance

James E. Cox, Pamela T. Brown, Raymond J. Toney, Deborah J. Wiebe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We compared changes in runway performance by rats for sucrose reward following injections of the synthetic C-terminal octapeptide of cholecystokinin (CCK-8) with those seen after variations in food deprivation and injections of lithium chloride. No effects on running for either 10% or 30% sucrose were found following 0.5 to 4.0 μg/kg of CCK-8, though such doses suppressed 30-min sucrose intake up to 53%. Statistically reliable slowing of running for 10% sucrose was observed on two series of tests after 8.0 μg/kg of CCK-8. Running for 30% sucrose was not significantly affected by this dose. The general ineffectiveness of CCK-8 for producing decrements in running spread contrasts with significantly reduced performance after either reductions in food deprivation (21 h vs 12 and 3 h) or injections of 75 mg/kg lithium chloride. These results suggest that the mode of action of CCK-8 in reducing food intake is different than that produced by changes in hunger or by non-specific interference with motivation by malaise. The finding that CCK-8 can substantially reduce consumption with no apparent changes in appetitive motivation is consistent with the hypothesis that this substance acts only late in the meal to prematurely trigger satiety.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalBehavioural Brain Research
Volume14
Issue number1
DOIs
StatePublished - 1984

Fingerprint

Sincalide
Cholecystokinin
Sucrose
Running
Lithium Chloride
Food Deprivation
Injections
Motivation
Hunger
Reward
Meals
Eating

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Ineffectiveness of cholecystokinin in impairing runway performance. / Cox, James E.; Brown, Pamela T.; Toney, Raymond J.; Wiebe, Deborah J.

In: Behavioural Brain Research, Vol. 14, No. 1, 1984, p. 41-50.

Research output: Contribution to journalArticle

Cox, James E. ; Brown, Pamela T. ; Toney, Raymond J. ; Wiebe, Deborah J. / Ineffectiveness of cholecystokinin in impairing runway performance. In: Behavioural Brain Research. 1984 ; Vol. 14, No. 1. pp. 41-50.
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