Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10

Zhenjun Lou, Chengcheng Zhang, Carlos A. Tirado, Tamra L Slone, Junke Zheng, Charles M. Zaremba, Dwight H Oliver, Weina Chen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);. MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.

Original languageEnglish (US)
Pages (from-to)1107-1109
Number of pages3
JournalLeukemia Research
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • Flow cytometry
  • MLL-MLLT10
  • Mixed phenotype acute leukemia
  • T(10 ;11)(p12 ;q23)

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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