Infection markers and early signs of neonatal encephalopathy in the term infant

Lina F. Shalak, Jeffrey M. Perlman

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Recent evidence points to an association between intrauterine infection and cerebral palsy (CP) in the preterm as well as the term infant. The mechanisms that link these two conditions are unclear. Chorioamnionitis is a common clinical problem complicating 5-10% of pregnancies, whereas the incidence of CP attributed to intrapartum asphyxia is rare. Chorioamnionitis may result in brain injury as a result of interruption of placental blood flow (asphyxia), or via fever and/or the cytokine release associated with infection. This review will attempt to establish the link between perinatal infection and brain damage in term infants. The characteristics of the perinatal inflammatory response, the potential mechanisms of brain injury associated with infection, and the clinical characteristics of neonatal encephalopathy will be discussed.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalMental Retardation and Developmental Disabilities Research Reviews
Volume8
Issue number1
DOIs
StatePublished - Jul 22 2002

Keywords

  • Chorioamnionitis
  • HIE
  • Inflammatory cytokines
  • Neonatal encephalopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)

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