Infections After Orthotopic Liver Transplantation

Mark Pedersen, Anil Seetharam

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Opportunistic infections are a leading cause of morbidity and mortality after orthotopic liver transplantation. Systemic immunosuppression renders the liver recipient susceptible to de novo infection with bacteria, viruses and fungi post-transplantation as well to reactivation of pre-existing, latent disease. Pathogens are also transmissible via the donor organ. The time from transplantation and degree of immunosuppression may guide the differential diagnosis of potential infectious agents. However, typical systemic signs and symptoms of infection are often absent or blunted after transplant and a high index of suspicion is needed. Invasive procedures are often required to procure tissue for culture and guide antimicrobial therapy. Antimicrobial prophylaxis reduces the incidence of opportunistic infections and is routinely employed in the care of patients after liver transplant. In this review, we survey common bacterial, fungal, and viral infections after orthotopic liver transplantation and highlight recent developments in their diagnosis and management.

Original languageEnglish (US)
Pages (from-to)347-360
Number of pages14
JournalJournal of Clinical and Experimental Hepatology
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Cytomegalovirus
  • Donor transmission
  • Infection
  • Liver transplantation
  • Prophylaxis

ASJC Scopus subject areas

  • Hepatology

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