"Inflammation and arterial stiffness in humans"

Snigdha Jain, Rohan Khera, Vicente F. Corrales-Medina, Raymond R. Townsend, Julio A. Chirinos

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalAtherosclerosis
Volume237
Issue number2
DOIs
Publication statusPublished - Dec 1 2014

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Keywords

  • Arterial stiffness
  • Cardiovascular risk
  • Inflammation
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Jain, S., Khera, R., Corrales-Medina, V. F., Townsend, R. R., & Chirinos, J. A. (2014). "Inflammation and arterial stiffness in humans". Atherosclerosis, 237(2), 381-390. https://doi.org/10.1016/j.atherosclerosis.2014.09.011