Abstract
PurposeTo update clinicians on the field of psychoneuroimmunology with respect to depression. Recent findingsA significant subset of patients with depression may have illness to which dysfunction of the immune system, typically viewed as inflammation, makes a significant contribution. Normal sickness behavior may sometimes manifest abnormally as mood episodes. Early evidence suggests that interventions that reduce inflammation may improve symptoms in these patients and that they may also respond differently to standard pharmacotherapy. SummaryTreatment of patients with depression should consider inflammatory status, as part of medical and psychiatric health. Recommendations for healthy diet and exercise are important for all patients but may be more important for patients who have clinical evidence of inflammation. Methods of identifying patients in the inflammatory subgroup and treating them with therapy targeted specifically at the immune system are still experimental but likely to impact care for depression in the future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 452-458 |
| Number of pages | 7 |
| Journal | Current Treatment Options in Psychiatry |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2018 |
| Externally published | Yes |
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Keywords
- Depression
- Immune System
- Inflamation
- Psychoneuroimmunology
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Inflammation and Depression : the Neuroimmune Connection. / Toups, Marisa.
In: Current Treatment Options in Psychiatry, Vol. 5, No. 4, 01.12.2018, p. 452-458.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Inflammation and Depression
T2 - the Neuroimmune Connection
AU - Toups, Marisa
PY - 2018/12/1
Y1 - 2018/12/1
N2 - PurposeTo update clinicians on the field of psychoneuroimmunology with respect to depression. Recent findingsA significant subset of patients with depression may have illness to which dysfunction of the immune system, typically viewed as inflammation, makes a significant contribution. Normal sickness behavior may sometimes manifest abnormally as mood episodes. Early evidence suggests that interventions that reduce inflammation may improve symptoms in these patients and that they may also respond differently to standard pharmacotherapy. SummaryTreatment of patients with depression should consider inflammatory status, as part of medical and psychiatric health. Recommendations for healthy diet and exercise are important for all patients but may be more important for patients who have clinical evidence of inflammation. Methods of identifying patients in the inflammatory subgroup and treating them with therapy targeted specifically at the immune system are still experimental but likely to impact care for depression in the future.
AB - PurposeTo update clinicians on the field of psychoneuroimmunology with respect to depression. Recent findingsA significant subset of patients with depression may have illness to which dysfunction of the immune system, typically viewed as inflammation, makes a significant contribution. Normal sickness behavior may sometimes manifest abnormally as mood episodes. Early evidence suggests that interventions that reduce inflammation may improve symptoms in these patients and that they may also respond differently to standard pharmacotherapy. SummaryTreatment of patients with depression should consider inflammatory status, as part of medical and psychiatric health. Recommendations for healthy diet and exercise are important for all patients but may be more important for patients who have clinical evidence of inflammation. Methods of identifying patients in the inflammatory subgroup and treating them with therapy targeted specifically at the immune system are still experimental but likely to impact care for depression in the future.
KW - Depression
KW - Immune System
KW - Inflamation
KW - Psychoneuroimmunology
UR - http://www.scopus.com/inward/record.url?scp=85065778851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065778851&partnerID=8YFLogxK
U2 - 10.1007/s40501-018-0157-x
DO - 10.1007/s40501-018-0157-x
M3 - Review article
VL - 5
SP - 452
EP - 458
JO - Current Treatment Options in Psychiatry
JF - Current Treatment Options in Psychiatry
SN - 2196-3061
IS - 4
ER -