Inflammatory effects of otic drops on the middle ear

Robert G. Anderson, Charles G. Wright, William L. Meyerhoff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Combination topical otic preparations are used to treat many infections of the external and middle ears. Despite the presence of ototoxic drugs in a number of these drops and convincing evidence of sensorineural hearing loss in humans and animal studies (Meyerhoff et al., presented at Southern Section Triological Meeting, Jan. 1983) following use of these medications, otic drops remain the cornerstone of treatment for many infectious disorders of the ear. Twelve chinchillas underwent bilateral tympanostomy tube placement and daily instillation of Cortisporin Otic Suspension (polymyxin B, neomycin, hydrocortisone, propylene glycol) in the right external auditory canal for 7 consecutive days. The animals were sacrificed 3 days later, 10 days following initiation of the Cortisporin Otic Suspension treatment. Following routine preparation of the temporal bones for light microscopy, the tissue was evaluated for evidence of inflammatory changes. All 12 animals demonstrated granulation tissue, effusion and focal hemorrhage in the ears subjected to the Cortisporin Otic Suspension. All of the contralateral control ears were normal. The present data suggest that this inflammatory response is due to a topical irritant effect of the otic preparation.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume7
Issue number2
DOIs
StatePublished - 1984

Fingerprint

Middle Ear
Ear
Suspensions
Middle Ear Ventilation
Chinchilla
External Ear
Propylene Glycol
Ear Canal
Granulation Tissue
Sensorineural Hearing Loss
Temporal Bone
Irritants
Microscopy
Hemorrhage
Light
hydrocortisone, neomycin, polymyxin B drug combination
Infection

Keywords

  • chinchilla
  • inflammation
  • middle ear
  • neomycin

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Inflammatory effects of otic drops on the middle ear. / Anderson, Robert G.; Wright, Charles G.; Meyerhoff, William L.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 7, No. 2, 1984, p. 91-95.

Research output: Contribution to journalArticle

Anderson, Robert G. ; Wright, Charles G. ; Meyerhoff, William L. / Inflammatory effects of otic drops on the middle ear. In: International Journal of Pediatric Otorhinolaryngology. 1984 ; Vol. 7, No. 2. pp. 91-95.
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