Inflammatory mediators of liver ischemia-reperfusion injury

Kyle B. Walsh, Alexander H. Toledo, Fernando A. Rivera-Chavez, Fernando Lopez-Neblina, Luis H. Toledo-Pereyra

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex,many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.

Original languageEnglish (US)
Pages (from-to)78-93
Number of pages16
JournalExperimental and Clinical Transplantation
Volume7
Issue number2
StatePublished - Jun 2009

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Reperfusion Injury
Liver
Selectins
Ischemic Preconditioning
Heme Oxygenase-1
Toll-Like Receptors
Wounds and Injuries
Erythropoietin
Heat-Shock Proteins
Matrix Metalloproteinases
Protein Kinases
Reperfusion
Reactive Oxygen Species
Nitric Oxide
Ischemia
Cytokines
T-Lymphocytes
Transplants
Therapeutics

Keywords

  • Inflammatory mediators
  • Ischemia and reperfusion
  • Liver
  • Transplant
  • Trauma

ASJC Scopus subject areas

  • Transplantation

Cite this

Walsh, K. B., Toledo, A. H., Rivera-Chavez, F. A., Lopez-Neblina, F., & Toledo-Pereyra, L. H. (2009). Inflammatory mediators of liver ischemia-reperfusion injury. Experimental and Clinical Transplantation, 7(2), 78-93.

Inflammatory mediators of liver ischemia-reperfusion injury. / Walsh, Kyle B.; Toledo, Alexander H.; Rivera-Chavez, Fernando A.; Lopez-Neblina, Fernando; Toledo-Pereyra, Luis H.

In: Experimental and Clinical Transplantation, Vol. 7, No. 2, 06.2009, p. 78-93.

Research output: Contribution to journalArticle

Walsh, KB, Toledo, AH, Rivera-Chavez, FA, Lopez-Neblina, F & Toledo-Pereyra, LH 2009, 'Inflammatory mediators of liver ischemia-reperfusion injury', Experimental and Clinical Transplantation, vol. 7, no. 2, pp. 78-93.
Walsh KB, Toledo AH, Rivera-Chavez FA, Lopez-Neblina F, Toledo-Pereyra LH. Inflammatory mediators of liver ischemia-reperfusion injury. Experimental and Clinical Transplantation. 2009 Jun;7(2):78-93.
Walsh, Kyle B. ; Toledo, Alexander H. ; Rivera-Chavez, Fernando A. ; Lopez-Neblina, Fernando ; Toledo-Pereyra, Luis H. / Inflammatory mediators of liver ischemia-reperfusion injury. In: Experimental and Clinical Transplantation. 2009 ; Vol. 7, No. 2. pp. 78-93.
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