Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor

Michael V. Ortiz, Christopher T. Rossi, D. Ashley Hill, Phillip C. Guzzetta, Faisal Qureshi, Jeffrey S. Dome

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 years after WT therapy consisting of VDA and abdominal XRT. The unlikely co-occurrence of WT and IMT suggests a genetic link between these tumors or that IMT can arise as a complication of cancer therapy. IMT should be considered in WT survivors who develop secondary tumors, especially at unusual sites.

Original languageEnglish (US)
Pages (from-to)1075-1077
Number of pages3
JournalPediatric Blood and Cancer
Volume62
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • ALK
  • Inflammatory myofibroblastic tumor
  • Second neoplasm
  • Wilms tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Ortiz, M. V., Rossi, C. T., Hill, D. A., Guzzetta, P. C., Qureshi, F., & Dome, J. S. (2015). Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor. Pediatric Blood and Cancer, 62(6), 1075-1077. https://doi.org/10.1002/pbc.25345