Influence of bivalent cations on the temperature of the phase transition in lipid membranes

V. S. Markin, M. M. Kozlov

Research output: Contribution to journalArticle

Abstract

A theory is developed explaining the temperature shift of the phase transition of the bilayer ΔTc, a consequence of the interaction of the charged polar heads of lipid molecules. It is shown that adsorption on a heavily charged membrane of monovalent cations raises the temperature of the transition by about 15 °C, this value not depending on the ionic strength and dielectric constant ε of the medium. On adsorption of bivalent cations the shift of the temperature of the transition is greater. The value ΔTc depends on ε of the medium in which the polar heads are present. If the membrane is in an electrolyte solution then ΔTc ≈ 19 °C; with the appearance between the membranes of dehydrated contact with low dielectric constant the temperature of the transition in this zone must, rise by about 160 °C which agrees with the experimental findings of Papahadjopoulos et al.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalBiophysics
Volume29
Issue number1
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Biophysics

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