Influence of cardiopulmonary bypass on platelet and neutrophil accumulations in internal organs

Rohan Bhujle, Jun Li, Parag Shastri, John N. Gaffke, James E. Clift, Yun Wei Ye, Michael L. Dollar, Peter Ching, Robert Chao, Anca Constantinescu, Padmakar V Kulkarni, Qin Chang Cheng, Frank Wians, Michael E Jessen, Robert C. Eberhart

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Gamma scintigraphy is used to quantify the post bypass accumulations of platelets and neutrophils in the lung, liver, and heart of adult pigs subjected to a standard 90 min regimen of normothermic cardiopulmonary bypass (CPB). Coated and uncoated microporous polypropylene oxygenator circuits were studied for Cobe Duo (Arvada, CO) oxygenators (amphophilic silicone-caprolactone oligomer [SMA] coating, n = 8 each) and Medtronic Maxima (Irvine, Ca) oxygenators (Carmeda heparin coating, n = 5 each). The SMA treatment significantly increased platelet accumulations versus uncoated controls in lung, liver, and heart for the 2 hr period, including the majority of the post CPB sampling intervals; platelet densities did not reach preCPB levels. Neutrophil accumulations were unaffected by the SMA coating.

Original languageEnglish (US)
Pages (from-to)M739-M744
JournalASAIO Journal
Volume43
Issue number5
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Influence of cardiopulmonary bypass on platelet and neutrophil accumulations in internal organs'. Together they form a unique fingerprint.

Cite this