Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: A report from the International Collaboration on Endocarditis - Merged Database

Wissam Kourany, Jose Miro, Asuncion Moreno, G. Ralph Corey, Paul Pappas, Elias Abrutyn, Bruno Hoen, Gilbert Habib, Vance Fowler, Daniel Sexton, Lars Olaison, Christopher Cabell, J. M. Miró, A. del Río, M. A. Baraldes, M. J. Jiménez-Expósito, N. de Benito, X. Claramonte, M. E. Díaz, A. SorianoA. Moreno, J. M. Gatell, F. Marco, C. García de la María, Y. Armero, M. Almela, M. T. Jiménez de Anta, J. C. Paré, M. Azqueta, C. A. Mestres, S. Ninot, R. Cartaǹa, J. L. Pomar, N. Pérez, J. Ramírez, T. Ribalta, P. Stolley, B. Hoen, C. Selton-Suty, T. Doco-Lecompte, F. Duchêne, N. Khayat, Y. Bernard, C. Chirouze, G. R. Corey, D. J. Sexton, V. G. Fowler, C. W. Woods, A. Wang, G. E. Peterson, J. G. Jollis, D. J. Anderson, R. Singh, C. H. Cabell, D. Glower, P. A. Pappas, J. Stafford, L. Olaison, A. Thalme, S. Eykyn, D. Raoult, G. Habib, J. P. Casalta, K. Barrau, P. E. Fournier, E. Abrutyn, B. L. Strom, J. A. Berlin, J. L. Kinman, R. S. Feldman, M. E. Levison, O. M. Korzeniowski, D. Kaye

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Abstract

The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0% vs 31.9%, p=0.01), more often had comorbidities (41.5% vs 26.7%, p<0.001), and were more likely to be dialysis dependent (12.7% vs 4.0%, p<0.001). S. aureus was isolated more often (30.7% vs 21.7%, p<0.02), and microorganisms from the viridans Streptococcus group less often (16.7% vs 28.2%, p=0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0% vs 44.9%, p=0.003), and had higher overall in-hospital mortality (30.3% vs 18.6%, p=0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) =1.71, 95% confidence interval (CI) 1.2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalScandinavian Journal of Infectious Diseases
Volume38
Issue number8
DOIs
StatePublished - Aug 2006

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Endocarditis
Diabetes Mellitus
Databases
Hospital Mortality
Odds Ratio
Confidence Intervals
Viridans Streptococci
Mortality
Embolism
Abscess
Comorbidity
Dialysis
Heart Failure

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis : A report from the International Collaboration on Endocarditis - Merged Database. / Kourany, Wissam; Miro, Jose; Moreno, Asuncion; Ralph Corey, G.; Pappas, Paul; Abrutyn, Elias; Hoen, Bruno; Habib, Gilbert; Fowler, Vance; Sexton, Daniel; Olaison, Lars; Cabell, Christopher; Miró, J. M.; del Río, A.; Baraldes, M. A.; Jiménez-Expósito, M. J.; de Benito, N.; Claramonte, X.; Díaz, M. E.; Soriano, A.; Moreno, A.; Gatell, J. M.; Marco, F.; García de la María, C.; Armero, Y.; Almela, M.; Jiménez de Anta, M. T.; Paré, J. C.; Azqueta, M.; Mestres, C. A.; Ninot, S.; Cartaǹa, R.; Pomar, J. L.; Pérez, N.; Ramírez, J.; Ribalta, T.; Stolley, P.; Hoen, B.; Selton-Suty, C.; Doco-Lecompte, T.; Duchêne, F.; Khayat, N.; Bernard, Y.; Chirouze, C.; Corey, G. R.; Sexton, D. J.; Fowler, V. G.; Woods, C. W.; Wang, A.; Peterson, G. E.; Jollis, J. G.; Anderson, D. J.; Singh, R.; Cabell, C. H.; Glower, D.; Pappas, P. A.; Stafford, J.; Olaison, L.; Thalme, A.; Eykyn, S.; Raoult, D.; Habib, G.; Casalta, J. P.; Barrau, K.; Fournier, P. E.; Abrutyn, E.; Strom, B. L.; Berlin, J. A.; Kinman, J. L.; Feldman, R. S.; Levison, M. E.; Korzeniowski, O. M.; Kaye, D.

In: Scandinavian Journal of Infectious Diseases, Vol. 38, No. 8, 08.2006, p. 613-619.

Research output: Contribution to journalArticle

Kourany, W, Miro, J, Moreno, A, Ralph Corey, G, Pappas, P, Abrutyn, E, Hoen, B, Habib, G, Fowler, V, Sexton, D, Olaison, L, Cabell, C, Miró, JM, del Río, A, Baraldes, MA, Jiménez-Expósito, MJ, de Benito, N, Claramonte, X, Díaz, ME, Soriano, A, Moreno, A, Gatell, JM, Marco, F, García de la María, C, Armero, Y, Almela, M, Jiménez de Anta, MT, Paré, JC, Azqueta, M, Mestres, CA, Ninot, S, Cartaǹa, R, Pomar, JL, Pérez, N, Ramírez, J, Ribalta, T, Stolley, P, Hoen, B, Selton-Suty, C, Doco-Lecompte, T, Duchêne, F, Khayat, N, Bernard, Y, Chirouze, C, Corey, GR, Sexton, DJ, Fowler, VG, Woods, CW, Wang, A, Peterson, GE, Jollis, JG, Anderson, DJ, Singh, R, Cabell, CH, Glower, D, Pappas, PA, Stafford, J, Olaison, L, Thalme, A, Eykyn, S, Raoult, D, Habib, G, Casalta, JP, Barrau, K, Fournier, PE, Abrutyn, E, Strom, BL, Berlin, JA, Kinman, JL, Feldman, RS, Levison, ME, Korzeniowski, OM & Kaye, D 2006, 'Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: A report from the International Collaboration on Endocarditis - Merged Database', Scandinavian Journal of Infectious Diseases, vol. 38, no. 8, pp. 613-619. https://doi.org/10.1080/00365540600617017
Kourany, Wissam ; Miro, Jose ; Moreno, Asuncion ; Ralph Corey, G. ; Pappas, Paul ; Abrutyn, Elias ; Hoen, Bruno ; Habib, Gilbert ; Fowler, Vance ; Sexton, Daniel ; Olaison, Lars ; Cabell, Christopher ; Miró, J. M. ; del Río, A. ; Baraldes, M. A. ; Jiménez-Expósito, M. J. ; de Benito, N. ; Claramonte, X. ; Díaz, M. E. ; Soriano, A. ; Moreno, A. ; Gatell, J. M. ; Marco, F. ; García de la María, C. ; Armero, Y. ; Almela, M. ; Jiménez de Anta, M. T. ; Paré, J. C. ; Azqueta, M. ; Mestres, C. A. ; Ninot, S. ; Cartaǹa, R. ; Pomar, J. L. ; Pérez, N. ; Ramírez, J. ; Ribalta, T. ; Stolley, P. ; Hoen, B. ; Selton-Suty, C. ; Doco-Lecompte, T. ; Duchêne, F. ; Khayat, N. ; Bernard, Y. ; Chirouze, C. ; Corey, G. R. ; Sexton, D. J. ; Fowler, V. G. ; Woods, C. W. ; Wang, A. ; Peterson, G. E. ; Jollis, J. G. ; Anderson, D. J. ; Singh, R. ; Cabell, C. H. ; Glower, D. ; Pappas, P. A. ; Stafford, J. ; Olaison, L. ; Thalme, A. ; Eykyn, S. ; Raoult, D. ; Habib, G. ; Casalta, J. P. ; Barrau, K. ; Fournier, P. E. ; Abrutyn, E. ; Strom, B. L. ; Berlin, J. A. ; Kinman, J. L. ; Feldman, R. S. ; Levison, M. E. ; Korzeniowski, O. M. ; Kaye, D. / Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis : A report from the International Collaboration on Endocarditis - Merged Database. In: Scandinavian Journal of Infectious Diseases. 2006 ; Vol. 38, No. 8. pp. 613-619.
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title = "Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: A report from the International Collaboration on Endocarditis - Merged Database",
abstract = "The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0{\%} vs 31.9{\%}, p=0.01), more often had comorbidities (41.5{\%} vs 26.7{\%}, p<0.001), and were more likely to be dialysis dependent (12.7{\%} vs 4.0{\%}, p<0.001). S. aureus was isolated more often (30.7{\%} vs 21.7{\%}, p<0.02), and microorganisms from the viridans Streptococcus group less often (16.7{\%} vs 28.2{\%}, p=0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0{\%} vs 44.9{\%}, p=0.003), and had higher overall in-hospital mortality (30.3{\%} vs 18.6{\%}, p=0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) =1.71, 95{\%} confidence interval (CI) 1.2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.",
author = "Wissam Kourany and Jose Miro and Asuncion Moreno and {Ralph Corey}, G. and Paul Pappas and Elias Abrutyn and Bruno Hoen and Gilbert Habib and Vance Fowler and Daniel Sexton and Lars Olaison and Christopher Cabell and Mir{\'o}, {J. M.} and {del R{\'i}o}, A. and Baraldes, {M. A.} and Jim{\'e}nez-Exp{\'o}sito, {M. J.} and {de Benito}, N. and X. Claramonte and D{\'i}az, {M. E.} and A. Soriano and A. Moreno and Gatell, {J. M.} and F. Marco and {Garc{\'i}a de la Mar{\'i}a}, C. and Y. Armero and M. Almela and {Jim{\'e}nez de Anta}, {M. T.} and Par{\'e}, {J. C.} and M. Azqueta and Mestres, {C. A.} and S. Ninot and R. Cartaǹa and Pomar, {J. L.} and N. P{\'e}rez and J. Ram{\'i}rez and T. Ribalta and P. Stolley and B. Hoen and C. Selton-Suty and T. Doco-Lecompte and F. Duch{\^e}ne and N. Khayat and Y. Bernard and C. Chirouze and Corey, {G. R.} and Sexton, {D. J.} and Fowler, {V. G.} and Woods, {C. W.} and A. Wang and Peterson, {G. E.} and Jollis, {J. G.} and Anderson, {D. J.} and R. Singh and Cabell, {C. H.} and D. Glower and Pappas, {P. A.} and J. Stafford and L. Olaison and A. Thalme and S. Eykyn and D. Raoult and G. Habib and Casalta, {J. P.} and K. Barrau and Fournier, {P. E.} and E. Abrutyn and Strom, {B. L.} and Berlin, {J. A.} and Kinman, {J. L.} and Feldman, {R. S.} and Levison, {M. E.} and Korzeniowski, {O. M.} and D. Kaye",
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T1 - Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis

T2 - A report from the International Collaboration on Endocarditis - Merged Database

AU - Kourany, Wissam

AU - Miro, Jose

AU - Moreno, Asuncion

AU - Ralph Corey, G.

AU - Pappas, Paul

AU - Abrutyn, Elias

AU - Hoen, Bruno

AU - Habib, Gilbert

AU - Fowler, Vance

AU - Sexton, Daniel

AU - Olaison, Lars

AU - Cabell, Christopher

AU - Miró, J. M.

AU - del Río, A.

AU - Baraldes, M. A.

AU - Jiménez-Expósito, M. J.

AU - de Benito, N.

AU - Claramonte, X.

AU - Díaz, M. E.

AU - Soriano, A.

AU - Moreno, A.

AU - Gatell, J. M.

AU - Marco, F.

AU - García de la María, C.

AU - Armero, Y.

AU - Almela, M.

AU - Jiménez de Anta, M. T.

AU - Paré, J. C.

AU - Azqueta, M.

AU - Mestres, C. A.

AU - Ninot, S.

AU - Cartaǹa, R.

AU - Pomar, J. L.

AU - Pérez, N.

AU - Ramírez, J.

AU - Ribalta, T.

AU - Stolley, P.

AU - Hoen, B.

AU - Selton-Suty, C.

AU - Doco-Lecompte, T.

AU - Duchêne, F.

AU - Khayat, N.

AU - Bernard, Y.

AU - Chirouze, C.

AU - Corey, G. R.

AU - Sexton, D. J.

AU - Fowler, V. G.

AU - Woods, C. W.

AU - Wang, A.

AU - Peterson, G. E.

AU - Jollis, J. G.

AU - Anderson, D. J.

AU - Singh, R.

AU - Cabell, C. H.

AU - Glower, D.

AU - Pappas, P. A.

AU - Stafford, J.

AU - Olaison, L.

AU - Thalme, A.

AU - Eykyn, S.

AU - Raoult, D.

AU - Habib, G.

AU - Casalta, J. P.

AU - Barrau, K.

AU - Fournier, P. E.

AU - Abrutyn, E.

AU - Strom, B. L.

AU - Berlin, J. A.

AU - Kinman, J. L.

AU - Feldman, R. S.

AU - Levison, M. E.

AU - Korzeniowski, O. M.

AU - Kaye, D.

PY - 2006/8

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N2 - The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0% vs 31.9%, p=0.01), more often had comorbidities (41.5% vs 26.7%, p<0.001), and were more likely to be dialysis dependent (12.7% vs 4.0%, p<0.001). S. aureus was isolated more often (30.7% vs 21.7%, p<0.02), and microorganisms from the viridans Streptococcus group less often (16.7% vs 28.2%, p=0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0% vs 44.9%, p=0.003), and had higher overall in-hospital mortality (30.3% vs 18.6%, p=0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) =1.71, 95% confidence interval (CI) 1.2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.

AB - The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0% vs 31.9%, p=0.01), more often had comorbidities (41.5% vs 26.7%, p<0.001), and were more likely to be dialysis dependent (12.7% vs 4.0%, p<0.001). S. aureus was isolated more often (30.7% vs 21.7%, p<0.02), and microorganisms from the viridans Streptococcus group less often (16.7% vs 28.2%, p=0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0% vs 44.9%, p=0.003), and had higher overall in-hospital mortality (30.3% vs 18.6%, p=0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) =1.71, 95% confidence interval (CI) 1.2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.

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