Influence of hemoglobin phenotype on the mean erythrocyte volume

R. G. Sheehan, E. P. Frenkel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurements. The present studies identified a 17.6% frequency of microcytosis in a population of nonanemic black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4% of Hgb AA, 18.6% of AS and 26.5% of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the α-gene complement and the β-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalActa Haematologica
Volume69
Issue number4
StatePublished - 1983

Fingerprint

Erythrocyte Volume
Hemoglobins
Phenotype
Erythrocyte Indices
Population
Erythrocytes
Genes

ASJC Scopus subject areas

  • Hematology

Cite this

Influence of hemoglobin phenotype on the mean erythrocyte volume. / Sheehan, R. G.; Frenkel, E. P.

In: Acta Haematologica, Vol. 69, No. 4, 1983, p. 260-265.

Research output: Contribution to journalArticle

@article{147f8829e6c74809abe97b2e7424c03f,
title = "Influence of hemoglobin phenotype on the mean erythrocyte volume",
abstract = "The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurements. The present studies identified a 17.6{\%} frequency of microcytosis in a population of nonanemic black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4{\%} of Hgb AA, 18.6{\%} of AS and 26.5{\%} of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the α-gene complement and the β-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.",
author = "Sheehan, {R. G.} and Frenkel, {E. P.}",
year = "1983",
language = "English (US)",
volume = "69",
pages = "260--265",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Influence of hemoglobin phenotype on the mean erythrocyte volume

AU - Sheehan, R. G.

AU - Frenkel, E. P.

PY - 1983

Y1 - 1983

N2 - The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurements. The present studies identified a 17.6% frequency of microcytosis in a population of nonanemic black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4% of Hgb AA, 18.6% of AS and 26.5% of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the α-gene complement and the β-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.

AB - The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurements. The present studies identified a 17.6% frequency of microcytosis in a population of nonanemic black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4% of Hgb AA, 18.6% of AS and 26.5% of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the α-gene complement and the β-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.

UR - http://www.scopus.com/inward/record.url?scp=0020697136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020697136&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 260

EP - 265

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 4

ER -