Influence of hemoglobin phenotype on the mean erythrocyte volume

R. G. Sheehan, E. P. Frenkel

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurements. The present studies identified a 17.6% frequency of microcytosis in a population of nonanemic black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4% of Hgb AA, 18.6% of AS and 26.5% of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the α-gene complement and the β-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalActa Haematologica
Volume69
Issue number4
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Influence of hemoglobin phenotype on the mean erythrocyte volume'. Together they form a unique fingerprint.

  • Cite this