Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients

J. T. Willerson, G. C. Curry, James M Atkins, R. Parkey, L. D. Horwitz

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The influence of a relatively small increase in serum osmolality produced by hypertonic mannitol on ventricular and systemic arterial hemodynamics and coronary blood flow was studied in 20 patients undergoing cardiac catheterization. Mannitol given to increase serum osmolality 10 mOsm resulted in a small but significant increase in mean systemic arterial pressure, maximum LV dp/dt, left ventricular end diastolic pressure and cardiac output but no significant change in heart rate or hematocrit. The most prominent change in the patients studied, however, was in coronary blood flow which increased 39% after mannitol. Patients with severe 2 and 3 vessel coronary blood flow which increases in coronary blood flow similar to those of patients without coronary artery disease. The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalCirculation
Volume51
Issue number6
StatePublished - 1975

Fingerprint

Mannitol
Coronary Artery Disease
Osmolar Concentration
Cardiac Catheterization
Serum
Hematocrit
Cardiac Output
Blood Vessels
Coronary Vessels
Arterial Pressure
Heart Rate
Hemodynamics
Blood Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Willerson, J. T., Curry, G. C., Atkins, J. M., Parkey, R., & Horwitz, L. D. (1975). Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients. Circulation, 51(6), 1095-1100.

Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients. / Willerson, J. T.; Curry, G. C.; Atkins, James M; Parkey, R.; Horwitz, L. D.

In: Circulation, Vol. 51, No. 6, 1975, p. 1095-1100.

Research output: Contribution to journalArticle

Willerson, JT, Curry, GC, Atkins, JM, Parkey, R & Horwitz, LD 1975, 'Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients', Circulation, vol. 51, no. 6, pp. 1095-1100.
Willerson, J. T. ; Curry, G. C. ; Atkins, James M ; Parkey, R. ; Horwitz, L. D. / Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients. In: Circulation. 1975 ; Vol. 51, No. 6. pp. 1095-1100.
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