TY - JOUR
T1 - Influence of multiparity on sympathetic nerve activity during normal pregnancy
AU - Badrov, Mark B.
AU - Yoo, Jeung Ki
AU - Steinback, Craig D.
AU - Davenport, Margie H.
AU - Fu, Qi
N1 - Funding Information:
This research was funded by National Heart, Lung, and Blood Institute Grant R21-HL-088184, American Heart Association Grant-in-Aid 13GRNT16990064, Harry S. Moss Heart Trust Awards 2015–2019, Lois Hole Hospital for Women through the Women and Children’s Health Research Institute Grant RES0018745, and Alberta Diabetes Institute Grant RES0036930. M. B. Badrov was supported by an American Autonomic Society-Lundbeck Postdoctoral Research Fellowship Award. C. D. Stein-back and M. H. Davenport are supported by a Heart and Stroke Foundation (HSFC) of Canada Grant-in-Aid G-16-00014033. M. H. Davenport is funded by a HSFC/Health Canada Improving Heart Health for Women Award, National and Alberta HSFC New Investigator Award (HSFC NNIA Davenport). C. D. Steinback is funded by a HSFC Joint National and Alberta New Investigator Award (HSFC NNIA Steinback).
Publisher Copyright:
Copyright © 2020 the American Physiological Society
PY - 2020/4
Y1 - 2020/4
N2 - Recent evidence suggests an elevated risk of cardiovascular disease development in multiparous women. Therefore, we investigated the effects of multiparity on within-pregnancy sympathetic neural regulation in normotensive, pregnant women. We retrospectively analyzed heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA; n = 8) data from 10 women whom participated in microneurographic research studies during two sequential pregnancies (i.e., PREG1 and PREG2). There was no difference in resting BP between pregnancies (P > 0.05), whereas HR trended higher in PREG2 versus PREG1 (P = 0.06). MSNA burst frequency was greater in PREG2 versus PREG1 after adjusting for age (32 ± 12 vs. 22 ± 12 bursts/min; P = 0.049), whereas burst incidence did not differ (40 ± 16 vs. 34 ± 17 bursts/100 heartbeats; P = 0.21). Sympathetic baroreflex sensitivity was not different between PREG1 and PREG2 (P > 0.05). Our results may highlight a possible role of altered within-pregnancy sympathetic neural regulation in the observed relationship in women between parity and future cardiovascular disease risk. NEW & NOTEWORTHY To our knowledge, this is the first study to investigate the effects of multiparity on within-pregnancy sympathetic neural regulation. We observed augmented muscle sympathetic nerve activity in women’s second studied pregnancy versus their first. Conversely, blood pressure and sympathetic baroreflex sensitivity did not differ, whereas a trend for increased heart rate was observed. Our results highlight a possible role of altered within-pregnancy sympathetic neural regulation in the relationship between increased parity and cardiovascular disease development.
AB - Recent evidence suggests an elevated risk of cardiovascular disease development in multiparous women. Therefore, we investigated the effects of multiparity on within-pregnancy sympathetic neural regulation in normotensive, pregnant women. We retrospectively analyzed heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA; n = 8) data from 10 women whom participated in microneurographic research studies during two sequential pregnancies (i.e., PREG1 and PREG2). There was no difference in resting BP between pregnancies (P > 0.05), whereas HR trended higher in PREG2 versus PREG1 (P = 0.06). MSNA burst frequency was greater in PREG2 versus PREG1 after adjusting for age (32 ± 12 vs. 22 ± 12 bursts/min; P = 0.049), whereas burst incidence did not differ (40 ± 16 vs. 34 ± 17 bursts/100 heartbeats; P = 0.21). Sympathetic baroreflex sensitivity was not different between PREG1 and PREG2 (P > 0.05). Our results may highlight a possible role of altered within-pregnancy sympathetic neural regulation in the observed relationship in women between parity and future cardiovascular disease risk. NEW & NOTEWORTHY To our knowledge, this is the first study to investigate the effects of multiparity on within-pregnancy sympathetic neural regulation. We observed augmented muscle sympathetic nerve activity in women’s second studied pregnancy versus their first. Conversely, blood pressure and sympathetic baroreflex sensitivity did not differ, whereas a trend for increased heart rate was observed. Our results highlight a possible role of altered within-pregnancy sympathetic neural regulation in the relationship between increased parity and cardiovascular disease development.
KW - Autonomic nervous system
KW - Cardiovascular disease
KW - Microneurography
KW - Pregnancy
KW - Sympathetic nerve activity
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U2 - 10.1152/ajpheart.00056.2020
DO - 10.1152/ajpheart.00056.2020
M3 - Article
C2 - 32142381
AN - SCOPUS:85082093556
SN - 0363-6135
VL - 318
SP - H816-H819
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 4
ER -