Influence of nanoparticle design on binding efficiency

Yaling Liu, Samar Shah, Walter Hu, Jinming Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The shape of nanoparticles plays a vital role in their transportation and adhesion in to cardiovascular system. The specific adhesion of nanoparticles to vascular surface has numerous potential applications such targeted drug delivery, biomedical imaging, and cancer treatment. This paper proposes a novel modeling method that provides insights of the dynamic interaction between nanoparticle and vessel wall. The ligand-receptor adhesion kinetics along with brownian dynamics is coupled with hydrodynamics to study the dynamic delivery process. The binding probability of two different shaped nanoparticles is evaluated and compared using Brownian adhesion dynamics model. Nanorod is found to contact and adhere to the wall surface easier than conventional nanosphere under same vascular flow conditions. This research work will explore the shape effect on targeted delivery process and eventually that will help researchers to design micro/nanoparticles for enhanced targeted adhesion to cells of interest.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
Pages265-266
Number of pages2
StatePublished - Aug 4 2010
Event1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010 - Houston, TX, United States
Duration: Feb 7 2010Feb 10 2010

Publication series

NameProceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010

Other

Other1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010
CountryUnited States
CityHouston, TX
Period2/7/102/10/10

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Liu, Y., Shah, S., Hu, W., & Gao, J. (2010). Influence of nanoparticle design on binding efficiency. In Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010 (pp. 265-266). (Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010).