Influence of surgical technique on mastectomy and reexcision rates in breast-conserving therapy for cancer

Alison Unzeitig, Anne Kobbermann, Xian Jin Xie, Jingsheng Yan, David Euhus, Yan Peng, Venetia Sarode, Amy Moldrem, A. Marilyn Leitch, Valerie Andrews, Roshni Rao

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20 Citations (Scopus)

Abstract

Introduction. Breast conserving surgery (BCS) requires tumor excision with negative margins. Reexcision rates of 30-50% are reported. Ultrasound localization, intraoperative margin pathology, and specimen mammography have reduced reexcisions, but require new equipment. Cavity shave margin (CSM) is a technique, utilizing existing equipment, that potentially reduces reexcision. This study evaluates CSM reexcision impact. Methods. 522 cancers treated with BCS were reviewed. Patients underwent standard partial mastectomy (SPM) or CSM. Data collected included demographics, pathology, and treatments. Results. 455 SPMs were compared to 67 CSMs. Analysis revealed no differences in pathology, intraductal component, or neoadjuvant chemotherapy. Overall reexcision rate = 43%. Most reexcisions were performed for DCIS at margin. SPMs underwent 213 reexcisions (46.8%), versus 16/67 (23.9%) CSMs (P = 0.0003). Total mastectomy as definitive procedure was performed after more SPMs (P = 0.009). Multivariate analysis revealed CSM, % DCIS, tumor size, and race to influence reexcisions. Conclusions. CSM is a technique that reduces reexcisions and mastectomy rates.

Original languageEnglish (US)
Article number725121
JournalInternational Journal of Surgical Oncology
Volume2012
DOIs
StatePublished - 2012

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Segmental Mastectomy
Mastectomy
Breast
Carcinoma, Intraductal, Noninfiltrating
Pathology
Simple Mastectomy
Equipment and Supplies
Neoplasms
Mammography
Therapeutics
Multivariate Analysis
Demography
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Influence of surgical technique on mastectomy and reexcision rates in breast-conserving therapy for cancer. / Unzeitig, Alison; Kobbermann, Anne; Xie, Xian Jin; Yan, Jingsheng; Euhus, David; Peng, Yan; Sarode, Venetia; Moldrem, Amy; Leitch, A. Marilyn; Andrews, Valerie; Rao, Roshni.

In: International Journal of Surgical Oncology, Vol. 2012, 725121, 2012.

Research output: Contribution to journalArticle

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AU - Unzeitig, Alison

AU - Kobbermann, Anne

AU - Xie, Xian Jin

AU - Yan, Jingsheng

AU - Euhus, David

AU - Peng, Yan

AU - Sarode, Venetia

AU - Moldrem, Amy

AU - Leitch, A. Marilyn

AU - Andrews, Valerie

AU - Rao, Roshni

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