Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms

Junyi Lei, Tong Tong Zou, Ying Qiang Shi, Xiaoling Zhou, Kara N. Smolinski, Jing Yin, Rhonda F. Souza, Rebecca Appel, Suna Wang, Karina Cymes, Olivia Chan, John M. Abraham, Noam Harpaz, Stephen J. Meltzer

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a recently identified candidate tumor suppressor gene, was previously shown to be altered in human pancreatic cancers. We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastric cancers and 10 colorectal cancers occurring in the preneoplastic condition, ulcerative colitis. The entire coding region of DPC4 (including all 11 exons) was analysed by either direct sequencing of PCR product or the in vitro synthesized protein assay. No coding region mutations of DPC4 were found in any of the samples examined. Our results suggest that inactivation of DPC4 may not be important in the majority of these types of gastrointestinal cancer.

Original languageEnglish (US)
Pages (from-to)2459-2462
Number of pages4
JournalOncogene
Volume13
Issue number11
Publication statusPublished - 1996

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Keywords

  • DNA sequencing
  • DPC4
  • Esophageal cancer
  • Gastric cancer
  • Mutation
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Lei, J., Zou, T. T., Shi, Y. Q., Zhou, X., Smolinski, K. N., Yin, J., ... Meltzer, S. J. (1996). Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene, 13(11), 2459-2462.