Inhalant allergy and Meniere's disease: Use of electrocochleography and intranasal allergen challenge as investigational tools

Courtney A. Noell, Peter S. Roland, Richard L. Mabry, Angela G. Shoup

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

INTRODUCTION: In an earlier study, we demonstrated the feasibility of using electrocochleography (ECoG) to document changes in inner ear function objectively after intranasal challenge of patients with inhalant allergy (with no prior immunotherapy) and Meniere's disease, using the antigen to which they were most sensitive. OBJECTIVE: We expand on this earlier study and continue to investigate the feasibility of this model in a subset of patients with inhalant allergy and Meniere's disease after immunotherapy. STUDY DESIGN: Prospective study of 11 patients identified with both Meniere's disease and inhalant allergy in the practices of 2 neurotologists at our institution. Patients underwent a baseline ECoG, followed by intranasal challenge with the allergen to which they were most sensitive. This was followed by a second ECoG. RESULTS: Six of 11 patients had at least 1 year of immunotherapy (group 1), and 5 of 11 had had 0 to 6 months of immunotherapy (group 2). Four of 6 group 1 patients had a > 15% increase in SP/AP ratio after immunotherapy. In group 2, 2 patients increased the SP/AP in at least 1 ear. No patient with a normal ECoG experienced vestibular symptoms after allergen challenge, whereas 2 of group 1 and 2 of group 2 had vestibular symptoms with abnormal ECoGs. CONCLUSION: This protocol is a useful tool for investigating the relationship of inhalant allergy and Meniere's disease, but needs a larger group of patients and further study to draw valid statistical conclusions.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume125
Issue number4
DOIs
StatePublished - Oct 2001

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Evoked Response Audiometry
Meniere Disease
Allergens
Hypersensitivity
Immunotherapy
Feasibility Studies
Inner Ear
Ear
Prospective Studies

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Inhalant allergy and Meniere's disease : Use of electrocochleography and intranasal allergen challenge as investigational tools. / Noell, Courtney A.; Roland, Peter S.; Mabry, Richard L.; Shoup, Angela G.

In: Otolaryngology - Head and Neck Surgery, Vol. 125, No. 4, 10.2001, p. 346-350.

Research output: Contribution to journalArticle

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