Abstract
Inherited diseases commonly emerge within pedigree dog populations, often due to use of repeatedly bred carrier sire(s) within a small gene pool. Accurate family records are usually available making linkage analysis possible. However, there are many factors that are intrinsically difficult about collecting DNA and collating pedigree information from a large canine population. The keys to a successful DNA collection program include (1) the need to establish and maintain support from the pedigree breed clubs and pet owners; (2) committed individual(s) who can devote the considerable amount of time and energy to coordinating sample collection and communicating with breeders and clubs; and (3) providing means by which genotypic and phenotypic information can be easily collected and stored. In this article we described the clinical characteristics of inherited occipital hypoplasia/syringomyelia (Chiari type I malformation) in the cavalier King Charles spaniel and our experiences in establishing a pedigree and DNA database to study the disease.
Original language | English (US) |
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Pages (from-to) | 745-749 |
Number of pages | 5 |
Journal | Journal of Heredity |
Volume | 96 |
Issue number | 7 |
DOIs | |
State | Published - Nov 2005 |
ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
- Genetics
- Genetics(clinical)