Inhibin-A levels and severity of hypertensive disorders due to pregnancy

Gerda G. Zeeman, James M. Alexander, Donald D. McIntire, William Byrd, Kenneth J. Leveno

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To evaluate the use of 3rd trimester inhibin-A levels as an adjunct to assess severity of hypertensive disorders due to pregnancy in women evaluated for preeclampsia. METHODS: Serum inhibin-A concentration was measured in a consecutive series of women evaluated for preeclampsia in the third trimester of pregnancy. RESULTS: Inhibin-A levels were significantly associated with the severity of proteinuric hypertensive disease due to pregnancy. Women with gestational hypertension or those with chronic hypertension without superimposed preeclampsia had levels comparable with normotensive women. The sensitivity to detect proteinuric hypertension was 16%. CONCLUSION: Although inhibin-A levels rise with increasing severity of disease, due to considerable overlap of normal and abnormal serum levels in women with and without preeclampsia, inhibin-A is not a useful adjunct for the classification of hypertensive disorders due to pregnancy.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalObstetrics and gynecology
Volume100
Issue number1
DOIs
StatePublished - Jul 15 2002

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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