Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan, S. Karthigayan, M. Sri Balasubashini, S. Vijayalakshmi, S. T. Somasundaram, T. Balasubramanian

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalInternational Journal of Cancer Research
Volume3
Issue number4
StatePublished - Oct 25 2007

Fingerprint

Elapid Venoms
Cell Proliferation
Growth
Ascites
Neoplasms
Carcinoma
Cell Culture Techniques
Injections
In Vitro Techniques

Keywords

  • Antitumor
  • Cell line
  • Ehrlich's ascites carcinoma
  • Hydrophis spiralis
  • Sea snake venom

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Karthikeyan, R., Karthigayan, S., Sri Balasubashini, M., Vijayalakshmi, S., Somasundaram, S. T., & Balasubramanian, T. (2007). Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. International Journal of Cancer Research, 3(4), 186-190.

Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. / Karthikeyan, R.; Karthigayan, S.; Sri Balasubashini, M.; Vijayalakshmi, S.; Somasundaram, S. T.; Balasubramanian, T.

In: International Journal of Cancer Research, Vol. 3, No. 4, 25.10.2007, p. 186-190.

Research output: Contribution to journalArticle

Karthikeyan, R, Karthigayan, S, Sri Balasubashini, M, Vijayalakshmi, S, Somasundaram, ST & Balasubramanian, T 2007, 'Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom', International Journal of Cancer Research, vol. 3, no. 4, pp. 186-190.
Karthikeyan, R. ; Karthigayan, S. ; Sri Balasubashini, M. ; Vijayalakshmi, S. ; Somasundaram, S. T. ; Balasubramanian, T. / Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. In: International Journal of Cancer Research. 2007 ; Vol. 3, No. 4. pp. 186-190.
@article{e16f43d6ae9c4003a936bcaca3e45726,
title = "Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom",
abstract = "The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81{\%}.",
keywords = "Antitumor, Cell line, Ehrlich's ascites carcinoma, Hydrophis spiralis, Sea snake venom",
author = "R. Karthikeyan and S. Karthigayan and {Sri Balasubashini}, M. and S. Vijayalakshmi and Somasundaram, {S. T.} and T. Balasubramanian",
year = "2007",
month = "10",
day = "25",
language = "English (US)",
volume = "3",
pages = "186--190",
journal = "International Journal of Cancer Research",
issn = "1811-9727",
publisher = "Asian Network for Scientific Information",
number = "4",

}

TY - JOUR

T1 - Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

AU - Karthikeyan, R.

AU - Karthigayan, S.

AU - Sri Balasubashini, M.

AU - Vijayalakshmi, S.

AU - Somasundaram, S. T.

AU - Balasubramanian, T.

PY - 2007/10/25

Y1 - 2007/10/25

N2 - The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

AB - The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

KW - Antitumor

KW - Cell line

KW - Ehrlich's ascites carcinoma

KW - Hydrophis spiralis

KW - Sea snake venom

UR - http://www.scopus.com/inward/record.url?scp=35348977763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348977763&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 186

EP - 190

JO - International Journal of Cancer Research

JF - International Journal of Cancer Research

SN - 1811-9727

IS - 4

ER -