Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan, S. Karthigayan, M. Sri Balasubashini, S. Vijayalakshmi, S. T. Somasundaram, T. Balasubramanian

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalInternational Journal of Cancer Research
Volume3
Issue number4
DOIs
StatePublished - 2007

Keywords

  • Antitumor
  • Cell line
  • Ehrlich's ascites carcinoma
  • Hydrophis spiralis
  • Sea snake venom

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Karthikeyan, R., Karthigayan, S., Sri Balasubashini, M., Vijayalakshmi, S., Somasundaram, S. T., & Balasubramanian, T. (2007). Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. International Journal of Cancer Research, 3(4), 186-190. https://doi.org/10.3923/ijcr.2007.186.190