Inhibition of cholinesterase and amyloid-β aggregation by resveratrol oligomers from Vitis amurensis

Hee Jang Moon, Lan Piao Xiang, Moon Kim Jong, Won Kwon Sung, Hill Park Jeong

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

In the course of screening for acetylcholinesterase and butyrylcholinesterase inhibitors from natural products by an in vitro Ellman method, the extract of the roots of Vitis amurensis Rupr. (Vitaceae) showed significant cholinesterase inhibitory activity. Employing a bioassay-linked HPLC method, followed by a semi-preparative HPLC method, two compounds of interest were isolated and characterized as vitisin A and heyneanol A. They inhibited effectively both acetylcholinesterase and butyrylcholinesterase in a dose-dependent manner and exhibited higher activity against butyrylcholinesterase compared with that of galantamine, a positive control. Furthermore, the aggregation of β-amyloid was evaluated in vitro based on a thioflavine T fluorescence assay to expand their activity profile, with the result that both compounds showed the ability to block β-amyloid aggregation.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalPhytotherapy Research
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2008

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Keywords

  • Anticholinesterase activity
  • Heyneanol A
  • Thioflavine T
  • Vitis amurensis
  • Vitisin A
  • β-amyloid aggregation

ASJC Scopus subject areas

  • Pharmacology

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