Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

R. Karthikeyan; S. Karthigayan; M. Sri Balasubashini; S. T. Somasundaram; T. Balasubramanian

doi:10.1016/j.toxicon.2007.08.012

Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

R. Karthikeyan, S. Karthigayan, M. Sri Balasubashini, S. T. Somasundaram, T. Balasubramanian

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.

Original language	English (US)
Pages (from-to)	157-161
Number of pages	5
Journal	Toxicon
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.toxicon.2007.08.012
State	Published - Jan 2008

Keywords

Antitumor
Cytotoxicity
Ehrlich's ascites carcinoma
Lapemis curtus
Sea snake venom

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/j.toxicon.2007.08.012

Cite this

@article{c3989ec8c03e449d8758bfda7de072fe,

title = "Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom",

abstract = "The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.",

keywords = "Antitumor, Cytotoxicity, Ehrlich's ascites carcinoma, Lapemis curtus, Sea snake venom",

author = "R. Karthikeyan and S. Karthigayan and {Sri Balasubashini}, M. and Somasundaram, {S. T.} and T. Balasubramanian",

year = "2008",

month = jan,

doi = "10.1016/j.toxicon.2007.08.012",

language = "English (US)",

volume = "51",

pages = "157--161",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

AU - Karthikeyan, R.

AU - Karthigayan, S.

AU - Sri Balasubashini, M.

AU - Somasundaram, S. T.

AU - Balasubramanian, T.

PY - 2008/1

Y1 - 2008/1

N2 - The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.

AB - The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.

KW - Antitumor

KW - Cytotoxicity

KW - Ehrlich's ascites carcinoma

KW - Lapemis curtus

KW - Sea snake venom

UR - http://www.scopus.com/inward/record.url?scp=38049095710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049095710&partnerID=8YFLogxK

U2 - 10.1016/j.toxicon.2007.08.012

DO - 10.1016/j.toxicon.2007.08.012

M3 - Article

C2 - 17936322

AN - SCOPUS:38049095710

SN - 0041-0101

VL - 51

SP - 157

EP - 161

JO - Toxicon

JF - Toxicon

IS - 1

ER -

Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this