Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

R. Karthikeyan, S. Karthigayan, M. Sri Balasubashini, S. T. Somasundaram, T. Balasubramanian

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalToxicon
Volume51
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Antitumor
  • Cytotoxicity
  • Ehrlich's ascites carcinoma
  • Lapemis curtus
  • Sea snake venom

ASJC Scopus subject areas

  • Toxicology

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