Inhibition of mitotic a aurora kinase a by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI -N78 cells

Medicine & Life Sciences

• MLN 8237 100%
• Aurora Kinases 85%
• Autophagy 54%
• Stomach Neoplasms 48%
• Apoptosis 34%
• Aurora Kinase A 25%
• Cell Cycle Checkpoints 12%
• TOR Serine-Threonine Kinases 9%
• p38 Mitogen-Activated Protein Kinases 8%
• Phosphatidylinositol 3-Kinase 8%
• Cell Proliferation 8%
• Cell Line 7%
• Mitochondria 7%
• CDC2 Protein Kinase 6%
• Cyclin B1 5%
• Wortmannin 5%
• Proto-Oncogene Proteins c-akt 5%
• Caspase 9 4%
• Protein-Serine-Threonine Kinases 4%
• Adenosine Monophosphate 4%
• G2 Phase 4%
• Mitogen-Activated Protein Kinase Kinases 4%
• Cytochromes c 4%
• Cell Division 4%
• Protein Kinases 4%
• Caspase 3 3%
• Cell Cycle 3%
• Proteins 3%
• Up-Regulation 3%
• Down-Regulation 3%
• Clinical Studies 3%
• Phosphorylation 2%
• Neoplasms 2%
• Drug Therapy 2%
• Growth 2%
• Therapeutics 0%

Chemical Compounds

• Aurora 88%
• Protein 23%
• Phosphatidylinositol 19%
• Wortmannin 13%
• Antiapoptotic 11%
• Threonine 9%
• Serine 7%
• Cytochrome 6%