Inhibition of prostaglandin-enhanced release of LH by antiserum to luteinizing hormone releasing hormone

R. L. Eskay, J. Warberg, J. C. Porter

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Prostaglandin E2 (PGE2), PGF2α, or PGF was infused into a lateral ventricle of the brain of adult male rats, after pretreatment with normal rabbit serum (NRS) or anti-LH-RH serum, and the concentration of LH in arterial plasma was determined. I.v. administration of anti-LH-RH serum 2.5 min prior to the infusion of 2 μg or 20 μg of PGE2 significantly inhibited the PGE2-induced rise of plasma LH. Intraventricular infusion of 20 μg of PGF2α or PGF into NRS-pretreated animals caused a marked increase in the plasma LH concentration; whereas, prior i.v. administration of anti-LH-RH serum blocked the PG-induced rise in plasma LH levels. It is concluded that PGE2, PGF2α, and PGF2β stimulate the release of LH primarily by enhancing the release of LH-RH.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalNeuroendocrinology
Volume24
Issue number5-6
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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