Prostaglandin E2 (PGE2), PGF2α, or PGF was infused into a lateral ventricle of the brain of adult male rats, after pretreatment with normal rabbit serum (NRS) or anti-LH-RH serum, and the concentration of LH in arterial plasma was determined. I.v. administration of anti-LH-RH serum 2.5 min prior to the infusion of 2 μg or 20 μg of PGE2 significantly inhibited the PGE2-induced rise of plasma LH. Intraventricular infusion of 20 μg of PGF2α or PGF into NRS-pretreated animals caused a marked increase in the plasma LH concentration; whereas, prior i.v. administration of anti-LH-RH serum blocked the PG-induced rise in plasma LH levels. It is concluded that PGE2, PGF2α, and PGF2β stimulate the release of LH primarily by enhancing the release of LH-RH.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience