Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra

P. K. Sonsalla, L. Manzino, C. M. Sinton, C. L. Liang, D. C. German, G. D. Zeevalk

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This study examined whether damage to dopamine (DA) nerve terminals via inhibition of energy metabolism in the striatum would result in the retrograde loss of cell bodies in the substantia nigra. Infusion of 2 μmol malonate into the left striatum of rats resulted in a 67% loss of striatal DA and a 40% loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. No change in the number of Nissl-positive-TH-negative neurons was observed. These findings demonstrate the retrograde destruction of DA cell bodies in the substantia nigra resulting from energy impairment at their terminal projection site.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalBrain Research
Volume773
Issue number1-2
DOIs
StatePublished - Oct 31 1997

    Fingerprint

Keywords

  • Cell loss
  • Dopamine
  • Malonate
  • Parkinson's disease
  • Striatum
  • Substantia nigra
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this