Inhibition of telomerase by BIBR 1532 and related analogues

D. K. Barma, Anissa Elayadi, J R Falck, David R Corey

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

BIBR 1532 has been reported to be a potent, small molecule inhibitor of human telomerase, suggesting it as a lead for the development of anti-telomerase therapy. We confirm the ability of BIBR 1532 to inhibit telomerase and report the discovery of an equally potent analogue. Importantly, IC50 values in cell extract are considerably higher than those previously reported using assays for purified enzyme, indicating that substantial improvement may be necessary.

Original languageEnglish (US)
Pages (from-to)1333-1336
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number7
DOIs
StatePublished - Apr 7 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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