Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

Agriculture & Biology

• glioblastoma 100%
• pyrimidines 76%
• transcription (genetics) 50%
• ribosomal RNA 48%
• biosynthesis 44%
• ribosomal DNA 22%
• cells 21%
• prognosis 18%
• transcription factors 11%
• brain neoplasms 11%
• nucleotides 10%
• glioma 9%
• nucleolus organizer region 9%
• uridine 8%
• DNA repair 8%
• ribosomes 7%
• neoplasm cells 6%
• enzymes 6%
• therapeutics 5%
• cell lines 5%
• culture media 5%
• brain 5%
• liver 4%
• synthesis 4%
• tissues 3%

Medicine & Life Sciences

• pyrimidine 84%
• Glioblastoma 67%
• Pyrimidines 32%
• Ribosomal DNA 26%
• Temozolomide 18%
• Cell Proliferation 15%
• brequinar 14%
• transcription factor UBF 12%
• Nucleotides 12%
• nucleophosmin 11%
• Nucleolus Organizer Region 10%
• DNA Repair Enzymes 10%
• Uridine 9%
• Ribosomes 7%
• Brain Neoplasms 7%
• Glioma 7%
• Culture Media 6%
• Transcription Factors 5%
• Pharmacology 5%
• Cell Line 4%
• Enzymes 4%
• Liver 3%
• Growth 3%
• Brain 3%
• In Vitro Techniques 3%
• Neoplasms 2%
• Therapeutics 1%

Earth & Environmental Sciences

• biosynthesis 76%
• cell 42%
• DNA 22%
• salvage 17%
• inhibitor 12%
• brain 12%
• enzyme 10%
• tumor 7%
• repair 6%
• cancer 6%
• stabilization 5%
• vulnerability 5%
• tissue 4%