Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Zhong Jian Shen, Sang Kook Kim, Young Sup Lee, Jong Won Lee, Byung Jo Moon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-β2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-β2 expression in U937 cells.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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