Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Zhong Jian Shen, Sang Kook Kim, Young Sup Lee, Jong Won Lee, Byung Jo Moon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-β2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-β2 expression in U937 cells.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number1
DOIs
StatePublished - Jan 1999

Fingerprint

Phosphorothioate Oligonucleotides
U937 Cells
Antisense Oligonucleotides
Transforming Growth Factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells. / Shen, Zhong Jian; Kim, Sang Kook; Lee, Young Sup; Lee, Jong Won; Moon, Byung Jo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 1, 01.1999, p. 13-18.

Research output: Contribution to journalArticle

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