Inhibitory effect of furosemide on carbonic anhydrase

Jianli Cui, Tongjin Zhao, Yan Jiang, Haimeng Zhou

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Abstract

This study investigated the inhibitory effect of a high efficiency diuretic, furosemide, on carbonic anhydrase (CA). First, comparing the inhibitory effect of acetazolamide, a low efficiency diuretic, on CA, shows that furosemide or acetazolamide can quickly make CA inactive when its concentration is close to the enzyme concentration, different from the usual inhibitory kinetics in which the concentration of the inhibitor is far higher than the enzyme concentration. Secondly, the reaction of the enzyme indicates that the inhibitory effect of furosemide or acetazolamide on carbonic anhydrase is quickly reversible. Finally, the degrees of the inhibitory effects of furosemide and of acetazolamide on CA are compared. The results show that furosemide inhibits CA less than acetazolamide.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalTsinghua Science and Technology
Volume11
Issue number4
DOIs
Publication statusPublished - Aug 2006

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Keywords

  • Acetazolamide
  • Carbonic anhydrase
  • Furosemide
  • Inhibition

ASJC Scopus subject areas

  • General

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