Inhibitory effect of intragastric glucose on gastric acid secretion and gastric emptying of liquids in man - Role of endogenous somatostatin, gastrin, and insulin

Haruka Sasaki, Murugasu Nagulesparan, Andre Dubois, Barbara Vasquez, Eugene Straus, Maurice L. Sievers, Roger H Unger

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Intragastric glucose inhibits gastric acid secretion and gastric emptying in man. To determine if these effects are mediated by somatostatin-a known inhibitor of gastric acid production, gastrin secretion, and gastric motility-the plasma somatostatin-like immunoreactivity (SLI) levels were determined in healthy human subjects after an intragastric load of 30% glucose solution. These findings were compared with results after an instillation of distilled water. Following the glucose load, the intragastric acid concentration, the acid output, and the fractional gastric emptying rate declined significantly (P<0.01) before either the plasma glucose or plasma insulin levels had increased. Neither the gastrin nor SLI plasma concentrations changed after the water or glucose load. These findings suggest that the suppression of gastric acid secretion and inhibition of the rate of gastric emptying that occur with intragastric glucose are mediated by factors other than changes in the peripheral circulating levels of SLI, gastrin, insulin, or glucose.

Original languageEnglish (US)
Pages (from-to)502-506
Number of pages5
JournalDigestive Diseases and Sciences
Issue number6
Publication statusPublished - Jun 1983


ASJC Scopus subject areas

  • Gastroenterology

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